Homing Missile is a weapon that appears in The 2nd Runner. It is a very useful weapon which launches multiple, powerful missiles that acquire individual targets. The number of missiles that can be launched is increased by pressing the circle button harder.
| Subweapons |
| Bounder · Comet · Decoy · Floating Mine · Gauntlet · Geyser · Halberd · Homing Missile · Javelin · Mummy · Phalanx · Sniper · Vector Cannon · Wisp · Zero Shift |